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46 similar compounds to monomer 50355499

Compile data set for download or QSAR
Wt: 403.4
BDBM97727
Wt: 417.4
BDBM97737
Wt: 431.4
BDBM97728
Wt: 420.4
BDBM119009
Wt: 366.4
BDBM119010
Wt: 448.5
BDBM119040
Wt: 361.4
BDBM119048
Wt: 418.5
BDBM119064
Wt: 332.3
BDBM119065
Wt: 417.5
BDBM120076
Wt: 529.5
BDBM120082
Wt: 383.4
BDBM50321361
Wt: 368.4
BDBM50321362
Wt: 403.4
BDBM50321363
Wt: 431.4
BDBM50321364
Displayed 1 to 15 (of 46 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 97727,97737,97728,119009,119010,119040,119048,119064,119065,120076,120082,50321361,50321362,50321363,50321364   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a 2.40n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321364
PNG
(4-cyano-N-(2-(4,4-dimethylcyclohex-1-enyl)-4-(2,6-...)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(=O)NC(=O)C1
Show InChI InChI=1S/C24H25N5O3/c1-24(2)7-5-14(6-8-24)18-9-15(16-10-20(30)29-21(31)11-16)3-4-19(18)28-23(32)22-26-13-17(12-25)27-22/h3-5,9,13,16H,6-8,10-11H2,1-2H3,(H,26,27)(H,28,32)(H,29,30,31)
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n/an/a 0.800n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a>3.20E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG potassium channel


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97727
PNG
(US8481564, 1)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CC(=O)NC(=O)C1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C22H21N5O3/c23-11-16-12-24-21(25-16)22(30)26-18-7-6-14(15-9-19(28)27-20(29)10-15)8-17(18)13-4-2-1-3-5-13/h4,6-8,12,15H,1-3,5,9-10H2,(H,24,25)(H,26,30)(H,27,28,29)
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n/an/a 1n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97728
PNG
(US8481564, 3)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(=O)NC(=O)C1
Show InChI InChI=1S/C24H25N5O3/c1-24(2)7-5-14(6-8-24)18-9-15(16-10-20(30)29-21(31)11-16)3-4-19(18)28-23(32)22-26-13-17(12-25)27-22/h3-5,9,13,16H,6-8,10-11H2,1-2H3,(H,26,27)(H,28,32)(H,29,30,31)
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n/an/a 1n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97737
PNG
(US8481564, 14)
Show SMILES CN1C(=O)CC(CC1=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H23N5O3/c1-28-20(29)10-16(11-21(28)30)15-7-8-19(18(9-15)14-5-3-2-4-6-14)27-23(31)22-25-13-17(12-24)26-22/h5,7-9,13,16H,2-4,6,10-11H2,1H3,(H,25,26)(H,27,31)
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n/an/a 1n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119065
PNG
(US8674100, 2)
Show SMILES CC(=C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O/c1-13(2)15-8-9-18(17(10-15)14-6-4-3-5-7-14)24-20(25)19-22-12-16(11-21)23-19/h6,8-10,12H,1,3-5,7H2,2H3,(H,22,23)(H,24,25)
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n/an/a 32.9n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119009
PNG
(US8674100, 6)
Show SMILES CC(C)(NC(=O)C(N)=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H24N6O3/c1-22(2,28-20(30)18(24)29)14-8-9-17(16(10-14)13-6-4-3-5-7-13)27-21(31)19-25-12-15(11-23)26-19/h6,8-10,12H,3-5,7H2,1-2H3,(H2,24,29)(H,25,26)(H,27,31)(H,28,30)
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n/an/a 8.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119010
PNG
(US8674100, 11)
Show SMILES OCC(CO)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H22N4O3/c21-9-16-10-22-19(23-16)20(27)24-18-7-6-14(15(11-25)12-26)8-17(18)13-4-2-1-3-5-13/h4,6-8,10,15,25-26H,1-3,5,11-12H2,(H,22,23)(H,24,27)
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n/an/a 60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119040
PNG
(US8674100, 53)
Show SMILES CN(C)CCNC(=O)Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H32N6O2/c1-25(2)9-7-18(8-10-25)20-13-17(14-22(32)27-11-12-31(3)4)5-6-21(20)30-24(33)23-28-16-19(15-26)29-23/h5-7,13,16H,8-12,14H2,1-4H3,(H,27,32)(H,28,29)(H,30,33)
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n/an/a 2.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119048
PNG
(US8674100, 68)
Show SMILES CNCC(=C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H23N5O/c1-14(12-23-2)16-8-9-19(18(10-16)15-6-4-3-5-7-15)26-21(27)20-24-13-17(11-22)25-20/h6,8-10,13,23H,1,3-5,7,12H2,2H3,(H,24,25)(H,26,27)
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n/an/a 1.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119064
PNG
(US8674100, 151)
Show SMILES CC1(C)CCC(=CC1)c1cc(CN2CCNCC2)ccc1NC(=O)c1ncc([nH]1)C#N
Show InChI InChI=1S/C24H30N6O/c1-24(2)7-5-18(6-8-24)20-13-17(16-30-11-9-26-10-12-30)3-4-21(20)29-23(31)22-27-15-19(14-25)28-22/h3-5,13,15,26H,6-12,16H2,1-2H3,(H,27,28)(H,29,31)
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n/an/a 0.820n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a 57n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The compounds of the present invention are also specific inhibitors of c-Kit. Selection of preferred compounds of Formula I for use as c-Kit inhibito...


US Patent US8697716 (2014)


BindingDB Entry DOI: 10.7270/Q2SN07NQ
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM120082
PNG
(US8697716, 47)
Show SMILES FC(F)(F)C(=O)OC(=O)CN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H26F3N5O4/c27-26(28,29)25(37)38-22(35)15-34-10-8-16(9-11-34)18-6-7-21(20(12-18)17-4-2-1-3-5-17)33-24(36)23-31-14-19(13-30)32-23/h4,6-7,12,14,16H,1-3,5,8-11,15H2,(H,31,32)(H,33,36)
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n/an/a 100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The compounds of the present invention are also specific inhibitors of c-Kit. Selection of preferred compounds of Formula I for use as c-Kit inhibito...


US Patent US8697716 (2014)


BindingDB Entry DOI: 10.7270/Q2SN07NQ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a 2n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Bioorg Med Chem Lett 18: 3632-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.059
BindingDB Entry DOI: 10.7270/Q2FN173T
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321361
PNG
(CHEMBL1172530 | N-(4'-amino-3-cyclohexenylbiphenyl...)
Show SMILES Nc1ccc(cc1)-c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H21N5O/c24-13-19-14-26-22(27-19)23(29)28-21-11-8-17(15-6-9-18(25)10-7-15)12-20(21)16-4-2-1-3-5-16/h4,6-12,14H,1-3,5,25H2,(H,26,27)(H,28,29)
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n/an/a 23n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321362
PNG
(4-cyano-N-(3-cyclohexenylbiphenyl-4-yl)-1H-imidazo...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1ccccc1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C23H20N4O/c24-14-19-15-25-22(26-19)23(28)27-21-12-11-18(16-7-3-1-4-8-16)13-20(21)17-9-5-2-6-10-17/h1,3-4,7-9,11-13,15H,2,5-6,10H2,(H,25,26)(H,27,28)
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n/an/a>60n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321363
PNG
(4-cyano-N-(2-cyclohexenyl-4-(2,6-dioxopiperidin-4-...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CC(=O)NC(=O)C1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H21N5O3/c23-11-16-12-24-21(25-16)22(30)26-18-7-6-14(15-9-19(28)27-20(29)10-15)8-17(18)13-4-2-1-3-5-13/h4,6-8,12,15H,1-3,5,9-10H2,(H,24,25)(H,26,30)(H,27,28,29)
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n/an/a 1n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a 5.60n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair