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42 similar compounds to monomer 50198782

Compile data set for download or QSAR
Wt: 411.2
BDBM97830
Wt: 411.2
BDBM97831
Wt: 469.5
BDBM97834
Wt: 427.5
BDBM97835
Wt: 469.5
BDBM97837
Wt: 523.4
BDBM97845
Wt: 523.4
BDBM97846
Wt: 537.4
BDBM97847
Wt: 519.4
BDBM97855
Wt: 495.4
BDBM97864
Wt: 519.4
BDBM97865
Wt: 440.5
BDBM97884
Wt: 441.5
BDBM97896
Wt: 457.5
BDBM97922
Wt: 475.9
BDBM97930
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 97830,97831,97834,97835,97837,97845,97846,97847,97855,97864,97865,97884,97896,97922,97930   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97830
PNG
(US8481536, 360)
Show SMILES COc1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C21H16Cl2N4O/c1-12-9-13(19-16(22)7-4-8-17(19)23)10-18-20(12)25-21(27-26-18)24-14-5-3-6-15(11-14)28-2/h3-11H,1-2H3,(H,24,25,27)
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n/an/a 189n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM97896
PNG
(US8481536, 457 | US8481536, 599)
Show SMILES Cc1cc2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2cc1-c1cccc(O)c1
Show InChI InChI=1S/C26H27N5O2/c1-18-15-24-25(17-23(18)19-5-4-6-21(32)16-19)29-30-26(28-24)27-20-7-9-22(10-8-20)33-14-13-31-11-2-3-12-31/h4-10,15-17,32H,2-3,11-14H2,1H3,(H,27,28,30)
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n/an/a 7.40n/an/an/an/an/an/a



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97834
PNG
(US8481536, 365)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCOCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O2/c1-19-5-4-6-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-7-9-24(10-8-23)35-16-13-33-11-14-34-15-12-33/h4-10,17-18H,11-16H2,1-3H3,(H,29,30,32)
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n/an/a 32.9n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97835
PNG
(US8481536, 374)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1cncnc1
Show InChI InChI=1S/C24H25N7O/c1-17-12-18(19-14-25-16-26-15-19)13-22-23(17)28-24(30-29-22)27-20-4-6-21(7-5-20)32-11-10-31-8-2-3-9-31/h4-7,12-16H,2-3,8-11H2,1H3,(H,27,28,30)
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n/an/a 1.50E+3n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97837
PNG
(US8481536, 378 | US8481536, 579)
Show SMILES Cc1cc(O)cc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O2/c1-18-15-23(34)16-19(2)26(18)21-14-20(3)27-25(17-21)31-32-28(30-27)29-22-6-8-24(9-7-22)35-13-12-33-10-4-5-11-33/h6-9,14-17,34H,4-5,10-13H2,1-3H3,(H,29,30,32)
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n/an/a 75n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97845
PNG
(US8481536, 389)
Show SMILES CN1CCN(CCOc2cccc(Nc3nnc4cc(cc(C)c4n3)-c3c(Cl)cccc3Cl)c2)CC1
Show InChI InChI=1S/C27H28Cl2N6O/c1-18-15-19(25-22(28)7-4-8-23(25)29)16-24-26(18)31-27(33-32-24)30-20-5-3-6-21(17-20)36-14-13-35-11-9-34(2)10-12-35/h3-8,15-17H,9-14H2,1-2H3,(H,30,31,33)
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n/an/a 27.4n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97846
PNG
(US8481536, 390)
Show SMILES CN1CCN(CCOc2ccc(Nc3nnc4cc(cc(C)c4n3)-c3c(Cl)cccc3Cl)cc2)CC1
Show InChI InChI=1S/C27H28Cl2N6O/c1-18-16-19(25-22(28)4-3-5-23(25)29)17-24-26(18)31-27(33-32-24)30-20-6-8-21(9-7-20)36-15-14-35-12-10-34(2)11-13-35/h3-9,16-17H,10-15H2,1-2H3,(H,30,31,33)
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n/an/a 23.2n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97847
PNG
(US8481536, 391)
Show SMILES CN1CCN(CCCOc2ccc(Nc3nnc4cc(cc(C)c4n3)-c3c(Cl)cccc3Cl)cc2)CC1
Show InChI InChI=1S/C28H30Cl2N6O/c1-19-17-20(26-23(29)5-3-6-24(26)30)18-25-27(19)32-28(34-33-25)31-21-7-9-22(10-8-21)37-16-4-11-36-14-12-35(2)13-15-36/h3,5-10,17-18H,4,11-16H2,1-2H3,(H,31,32,34)
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n/an/a 25.2n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97855
PNG
(US8481536, 401)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(C#N)c(OCCN4CCCC4)c3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C27H24Cl2N6O/c1-17-13-19(25-21(28)5-4-6-22(25)29)14-23-26(17)32-27(34-33-23)31-20-8-7-18(16-30)24(15-20)36-12-11-35-9-2-3-10-35/h4-8,13-15H,2-3,9-12H2,1H3,(H,31,32,34)
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n/an/a 21n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97864
PNG
(US8481536, 412)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)nc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H24Cl2N6O/c1-16-13-17(23-19(26)5-4-6-20(23)27)14-21-24(16)30-25(32-31-21)29-18-7-8-22(28-15-18)34-12-11-33-9-2-3-10-33/h4-8,13-15H,2-3,9-12H2,1H3,(H,29,30,32)
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n/an/a 15.3n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97865
PNG
(US8481536, 413)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)c(c3)C#N)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C27H24Cl2N6O/c1-17-13-18(25-21(28)5-4-6-22(25)29)15-23-26(17)32-27(34-33-23)31-20-7-8-24(19(14-20)16-30)36-12-11-35-9-2-3-10-35/h4-8,13-15H,2-3,9-12H2,1H3,(H,31,32,34)
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n/an/a 25.2n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97884
PNG
(US8481536, 442)
Show SMILES Cc1ccncc1-c1cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc2cc1C
Show InChI InChI=1S/C26H28N6O/c1-18-9-10-27-17-23(18)22-16-25-24(15-19(22)2)29-26(31-30-25)28-20-5-7-21(8-6-20)33-14-13-32-11-3-4-12-32/h5-10,15-17H,3-4,11-14H2,1-2H3,(H,28,29,31)
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n/an/a 44.3n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97896
PNG
(US8481536, 457 | US8481536, 599)
Show SMILES Cc1cc2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2cc1-c1cccc(O)c1
Show InChI InChI=1S/C26H27N5O2/c1-18-15-24-25(17-23(18)19-5-4-6-21(32)16-19)29-30-26(28-24)27-20-7-9-22(10-8-20)33-14-13-31-11-2-3-12-31/h4-10,15-17,32H,2-3,11-14H2,1H3,(H,27,28,30)
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n/an/a 17.7n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97922
PNG
(US8481536, 487)
Show SMILES Cc1cc(F)ccc1-c1cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc2cc1C
Show InChI InChI=1S/C27H28FN5O/c1-18-15-20(28)5-10-23(18)24-17-26-25(16-19(24)2)30-27(32-31-26)29-21-6-8-22(9-7-21)34-14-13-33-11-3-4-12-33/h5-10,15-17H,3-4,11-14H2,1-2H3,(H,29,30,32)
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n/an/a 26.1n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97930
PNG
(US8481536, 497)
Show SMILES Cc1cc(cc2nnc(Nc3cccc(OCCN4CCCC4)c3)nc12)-c1cc(O)ccc1Cl
Show InChI InChI=1S/C26H26ClN5O2/c1-17-13-18(22-16-20(33)7-8-23(22)27)14-24-25(17)29-26(31-30-24)28-19-5-4-6-21(15-19)34-12-11-32-9-2-3-10-32/h4-8,13-16,33H,2-3,9-12H2,1H3,(H,28,29,31)
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n/an/a 1.80n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM97837
PNG
(US8481536, 378 | US8481536, 579)
Show SMILES Cc1cc(O)cc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O2/c1-18-15-23(34)16-19(2)26(18)21-14-20(3)27-25(17-21)31-32-28(30-27)29-22-6-8-24(9-7-22)35-13-12-33-10-4-5-11-33/h6-9,14-17,34H,4-5,10-13H2,1-3H3,(H,29,30,32)
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n/an/a 41.1n/an/an/an/an/an/a



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM97831
PNG
(US8481536, 361)
Show SMILES COc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C21H16Cl2N4O/c1-12-10-13(19-16(22)4-3-5-17(19)23)11-18-20(12)25-21(27-26-18)24-14-6-8-15(28-2)9-7-14/h3-11H,1-2H3,(H,24,25,27)
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n/an/a 137n/an/an/an/an/a25



TargeGen Inc

US Patent


Assay Description
Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.


US Patent US8481536 (2013)


BindingDB Entry DOI: 10.7270/Q2GB22PZ
More data for this
Ligand-Target Pair