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There are 9 purchasable compounds for target: cPLA2

Compile data set for download or QSAR
Wt: 575.6
BDBM50009073
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Wt: 356.4
BDBM50059523
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Wt: 538.4
BDBM50129952
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Wt: 370.4
BDBM50132713
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Wt: 495.9
BDBM50180057
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Wt: 538.4
BDBM50183250
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Wt: 523.6
BDBM50185354
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Wt: 849.9
BDBM50205527
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Wt: 335.7
BDBM50056734
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50009073,50059523,50129952,50132713,50180057,50183250,50185354,50205527,50056734   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cPLA2 C2


(Homo sapiens (Human))
BDBM50009073
PNG
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Show SMILES COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
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n/an/a 8.50E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibition of cystolic phospholipase A2 alpha.


Bioorg Med Chem Lett 13: 4501-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.070
BindingDB Entry DOI: 10.7270/Q2W095BN
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50059523
PNG
((6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
Show InChI InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cPLA2-alpha activity


Bioorg Med Chem 16: 3489-500 (2008)


Article DOI: 10.1016/j.bmc.2008.02.019
BindingDB Entry DOI: 10.7270/Q2W66MN0
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Bos taurus)
BDBM50059523
PNG
((6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
Show InChI InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 1.10E+4n/an/an/an/an/an/a



Ludwig-Maximilians-University

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 measuring Calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets with HPLC/UV detection.


J Med Chem 40: 3381-92 (1997)


Article DOI: 10.1021/jm970045j
BindingDB Entry DOI: 10.7270/Q2KP818T
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50180057
PNG
(4-(2-(1-benzhydryl-2-methyl-1H-indol-3-yl)ethoxy)b...)
Show SMILES Cc1c(CCOc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H26ClNO3/c1-21-27(18-19-36-26-15-12-24(13-16-26)31(34)35)28-20-25(32)14-17-29(28)33(21)30(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-17,20,30H,18-19H2,1H3,(H,34,35)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha by GLU micelle assay


Bioorg Med Chem Lett 16: 2978-81 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.067
BindingDB Entry DOI: 10.7270/Q2FT8KM2
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50180057
PNG
(4-(2-(1-benzhydryl-2-methyl-1H-indol-3-yl)ethoxy)b...)
Show SMILES Cc1c(CCOc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H26ClNO3/c1-21-27(18-19-36-26-15-12-24(13-16-26)31(34)35)28-20-25(32)14-17-29(28)33(21)30(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-17,20,30H,18-19H2,1H3,(H,34,35)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of cytosolic phospholipase A2-alpha in GLU micelle assay


J Med Chem 49: 135-58 (2006)


Article DOI: 10.1021/jm0507882
BindingDB Entry DOI: 10.7270/Q2MC8ZMP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185354
PNG
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
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n/an/a 0.900n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)


Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185354
PNG
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
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n/an/a 4.30n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay


J Med Chem 49: 2611-20 (2006)


Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50185354
PNG
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)
Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1
Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
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n/an/a 570n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha activity assessed by A23187-induced arachidonic acid release in human platelet


J Med Chem 49: 2611-20 (2006)


Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50129952
PNG
(2-(3-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-c...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(O)cc4=O)o3)c2o1
Show InChI InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-33,35-37H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of human cloned cPLA2 expressed in HEK293 cells


Bioorg Med Chem 15: 7138-43 (2007)


Article DOI: 10.1016/j.bmc.2007.07.054
BindingDB Entry DOI: 10.7270/Q2WM1D5G
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50183250
PNG
(2-(3-(4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)pheno...)
Show SMILES Oc1cc2oc(cc(O)c2c(=O)c1)-c1ccc(Oc2cc(ccc2O)-c2cc(O)c3c(cc(O)cc3=O)o2)cc1
Show InChI InChI=1S/C30H18O10/c31-16-8-20(34)29-22(36)12-24(39-27(29)10-16)14-1-4-18(5-2-14)38-26-7-15(3-6-19(26)33)25-13-23(37)30-21(35)9-17(32)11-28(30)40-25/h1-13,31-33,36-37H
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Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of human cloned cPLA2 expressed in HEK293 cells


Bioorg Med Chem 15: 7138-43 (2007)


Article DOI: 10.1016/j.bmc.2007.07.054
BindingDB Entry DOI: 10.7270/Q2WM1D5G
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50205527
PNG
(CHEMBL221504 | N-(((2S,4R)-1-(2-(2,4-difluorobenzo...)
Show SMILES Fc1ccc(C(=O)c2ccccc2C(=O)N2C[C@@H](C[C@H]2CNC(=O)c2ccc(\C=C3/SC(=O)NC3=O)cc2)SC(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)c1
Show InChI InChI=1S/C49H37F2N3O5S2/c50-36-24-25-41(42(51)27-36)44(55)39-18-10-11-19-40(39)47(58)54-30-38(28-37(54)29-52-45(56)32-22-20-31(21-23-32)26-43-46(57)53-48(59)60-43)61-49(33-12-4-1-5-13-33,34-14-6-2-7-15-34)35-16-8-3-9-17-35/h1-27,37-38H,28-30H2,(H,52,56)(H,53,57,59)/b43-26-/t37-,38+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cPLA2 alpha by GLU micelle assay


J Med Chem 50: 1380-400 (2007)


Article DOI: 10.1021/jm061131z
BindingDB Entry DOI: 10.7270/Q23F4PB9
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50180057
PNG
(4-(2-(1-benzhydryl-2-methyl-1H-indol-3-yl)ethoxy)b...)
Show SMILES Cc1c(CCOc2ccc(cc2)C(O)=O)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H26ClNO3/c1-21-27(18-19-36-26-15-12-24(13-16-26)31(34)35)28-20-25(32)14-17-29(28)33(21)30(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-17,20,30H,18-19H2,1H3,(H,34,35)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cPLA2 alpha by GLU micelle assay


J Med Chem 50: 1380-400 (2007)


Article DOI: 10.1021/jm061131z
BindingDB Entry DOI: 10.7270/Q23F4PB9
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50059523
PNG
((6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
Show InChI InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Münster

Curated by ChEMBL


Assay Description
Inhibition of human platelet cPLA2-alpha assessed as arachidonic acid release by vesicle assay


Bioorg Med Chem 15: 2883-91 (2007)


Article DOI: 10.1016/j.bmc.2007.02.016
BindingDB Entry DOI: 10.7270/Q24749JP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50056734
PNG
(CHEMBL3327096)
Show SMILES OC(=O)\C=C\c1ccc(Sc2ccc(Cl)cc2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C15H10ClNO4S/c16-11-3-5-12(6-4-11)22-14-7-1-10(2-8-15(18)19)9-13(14)17(20)21/h1-9H,(H,18,19)/b8-2+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50132713
PNG
(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
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n/an/a 640n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)


Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (Human))
BDBM50059523
PNG
((6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
Show InChI InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC


Bioorg Med Chem 18: 945-52 (2010)


Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF
More data for this
Ligand-Target Pair
Cytosolic phospholipase A2


(Bos taurus)
BDBM50059523
PNG
((6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
Show InChI InChI=1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 1.10E+4n/an/an/an/an/an/a



Ludwig-Maximilians-University

Curated by ChEMBL


Assay Description
Inhibitory activity against cPLA2 (cytosolic Phospholipase A2) by measuring the calcium ionophore A-23,187-induced arachidonic acid release from bovi...


J Med Chem 40: 2694-705 (1997)


Article DOI: 10.1021/jm960863w
BindingDB Entry DOI: 10.7270/Q2NP23JK
More data for this
Ligand-Target Pair