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There are 23 purchasable compounds for target: Endothelin receptor

Compile data set for download or QSAR
Wt: 348.3
BDBM50711
Purchase
Wt: 255.3
BDBM50027796
Purchase
Wt: 253.2
BDBM50029770
Purchase
Wt: 267.3
BDBM50034433
Purchase
Wt: 253.2
BDBM50034474
Purchase
Wt: 309.3
BDBM50034479
Purchase
Wt: 267.3
BDBM50034452
Purchase
Wt: 506.5
BDBM50034267
Purchase
Wt: 256.3
BDBM50034417
Purchase
Wt: 256.3
BDBM50034424
Purchase
Wt: 510.6
BDBM50051007
Purchase
Wt: 454.9
BDBM50058126
Purchase
Wt: 551.6
BDBM50061101
Purchase
Wt: 463.3
BDBM50094703
Purchase
Wt: 550.6
BDBM50105000
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Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50711,50027796,50029770,50034433,50034474,50034479,50034452,50034267,50034417,50034424,50051007,50058126,50061101,50094703,50105000   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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0.0340n/an/an/an/an/an/an/an/a



Encysive Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards Endothelin A receptor


J Med Chem 47: 1969-86 (2004)


Article DOI: 10.1021/jm030528p
BindingDB Entry DOI: 10.7270/Q2HD7WD6
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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0.0470n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
binding affinity against human Endothelin A receptor


J Med Chem 44: 3978-84 (2001)


Article DOI: 10.1021/jm010237l
BindingDB Entry DOI: 10.7270/Q2JS9PR2
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50058126
PNG
(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3OCOc3cc2C)c1Cl
Show InChI InChI=1S/C18H15ClN2O6S2/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18/h3-5,7,21H,6,8H2,1-2H3
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0.430n/an/an/an/an/an/an/an/a



Encysive Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards Endothelin A receptor


J Med Chem 47: 1969-86 (2004)


Article DOI: 10.1021/jm030528p
BindingDB Entry DOI: 10.7270/Q2HD7WD6
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50061101
PNG
(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Show SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Show InChI InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
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6.5n/an/an/an/an/an/an/an/a



Encysive Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards Endothelin A receptor


J Med Chem 47: 1969-86 (2004)


Article DOI: 10.1021/jm030528p
BindingDB Entry DOI: 10.7270/Q2HD7WD6
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50094703
PNG
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1156-64 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6PSP
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50094703
PNG
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1156-64 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6PSP
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034452
PNG
(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
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n/an/a 780n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50029770
PNG
(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
Show InChI InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034479
PNG
(CHEMBL725 | N-[4-(3,4-Dimethyl-isoxazol-5-ylsulfam...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C13H15N3O4S/c1-8-9(2)15-20-13(8)16-21(18,19)12-6-4-11(5-7-12)14-10(3)17/h4-7,16H,1-3H3,(H,14,17)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50027796
PNG
(2-(Sulfanilylamino)thiazole | 2-(p-Aminobenzenesul...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
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n/an/a 6.90E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034433
PNG
(4-Amino-N-(4,5-dimethyl-isoxazol-3-yl)-benzenesulf...)
Show SMILES Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells


J Med Chem 38: 659-68 (1995)


Article DOI: 10.1021/jm00004a012
BindingDB Entry DOI: 10.7270/Q2D799G5
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50029770
PNG
(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
Show InChI InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells


J Med Chem 38: 659-68 (1995)


Article DOI: 10.1021/jm00004a012
BindingDB Entry DOI: 10.7270/Q2D799G5
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034452
PNG
(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
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n/an/a 800n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells


J Med Chem 38: 659-68 (1995)


Article DOI: 10.1021/jm00004a012
BindingDB Entry DOI: 10.7270/Q2D799G5
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 0.310n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against the Endothelin A receptor of rat MMQ cells


J Med Chem 39: 1039-48 (1996)


Article DOI: 10.1021/jm9505369
BindingDB Entry DOI: 10.7270/Q29G5KWT
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]-ET-1 as radioligand.


J Med Chem 40: 322-30 (1997)


Article DOI: 10.1021/jm960077r
BindingDB Entry DOI: 10.7270/Q20C4TV2
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034267
PNG
(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Show SMILES COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OC)c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C28H26O9/c1-31-19-8-6-18(7-9-19)28(30)20(11-16-12-23(32-2)26(34-4)24(13-16)33-3)25(27(29)37-28)17-5-10-21-22(14-17)36-15-35-21/h5-10,12-14,30H,11,15H2,1-4H3
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n/an/a 0.440n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptor


Bioorg Med Chem Lett 8: 17-22 (1999)


Article DOI: 10.1016/s0960-894x(97)10151-2
BindingDB Entry DOI: 10.7270/Q23B5Z9H
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034433
PNG
(4-Amino-N-(4,5-dimethyl-isoxazol-3-yl)-benzenesulf...)
Show SMILES Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor


Bioorg Med Chem Lett 10: 1875-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00366-8
BindingDB Entry DOI: 10.7270/Q2CJ8CQJ
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50029770
PNG
(4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonam...)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
Show InChI InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
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n/an/a 3.33E+5n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor


Bioorg Med Chem Lett 10: 1875-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00366-8
BindingDB Entry DOI: 10.7270/Q2CJ8CQJ
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034452
PNG
(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor


Bioorg Med Chem Lett 10: 1875-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00366-8
BindingDB Entry DOI: 10.7270/Q2CJ8CQJ
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50105000
PNG
(CHEMBL175616 | sodium salt of 4-tert-Butyl-N-[6-(2...)
Show SMILES COc1ccccc1Oc1c([N-]S(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Show InChI InChI=1S/C27H28N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3/q-1
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n/an/a 1.40n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro for specific binding of [125I]-ET-1 to A10 cell expressed in endothelin A receptor


J Med Chem 44: 3355-68 (2001)


Article DOI: 10.1021/jm0102304
BindingDB Entry DOI: 10.7270/Q2QN662B
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 0.360n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Endothelin A receptor in MMQ cells in rat


J Med Chem 44: 3978-84 (2001)


Article DOI: 10.1021/jm010237l
BindingDB Entry DOI: 10.7270/Q2JS9PR2
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 0.0800n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human Endothelin A receptor


J Med Chem 44: 3978-84 (2001)


Article DOI: 10.1021/jm010237l
BindingDB Entry DOI: 10.7270/Q2JS9PR2
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034433
PNG
(4-Amino-N-(4,5-dimethyl-isoxazol-3-yl)-benzenesulf...)
Show SMILES Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 0.310n/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.


J Med Chem 47: 2750-60 (2004)


Article DOI: 10.1021/jm031041j
BindingDB Entry DOI: 10.7270/Q26T0M3J
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50061101
PNG
(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Show SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Show InChI InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
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n/an/a 95n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Displacement of [125I]ET-1 from rat ETB receptor after 1 hr by Lowry method


Bioorg Med Chem 23: 657-67 (2015)


Article DOI: 10.1016/j.bmc.2015.01.003
BindingDB Entry DOI: 10.7270/Q28K7BRM
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50061101
PNG
(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Show SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Show InChI InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
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n/an/a 4.70n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method


Bioorg Med Chem 23: 657-67 (2015)


Article DOI: 10.1016/j.bmc.2015.01.003
BindingDB Entry DOI: 10.7270/Q28K7BRM
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor


Bioorg Med Chem Lett 8: 1771-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00301-1
BindingDB Entry DOI: 10.7270/Q2TM7BM4
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034424
PNG
(4-Hydroxy-N-thiazol-2-yl-benzenesulfonamide | CHEM...)
Show SMILES Oc1ccc(cc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N2O3S2/c12-7-1-3-8(4-2-7)16(13,14)11-9-10-5-6-15-9/h1-6,12H,(H,10,11)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50051007
PNG
((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Show SMILES CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1
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n/an/a 0.310n/an/an/an/an/an/a



Encysive Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration towards endothelin A receptor in rat.


J Med Chem 47: 1969-86 (2004)


Article DOI: 10.1021/jm030528p
BindingDB Entry DOI: 10.7270/Q2HD7WD6
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034417
PNG
(4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50058126
PNG
(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3OCOc3cc2C)c1Cl
Show InChI InChI=1S/C18H15ClN2O6S2/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18/h3-5,7,21H,6,8H2,1-2H3
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n/an/a 1.40n/an/an/an/an/an/a



Encysive Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration towards endothelin A receptor in rat.


J Med Chem 47: 1969-86 (2004)


Article DOI: 10.1021/jm030528p
BindingDB Entry DOI: 10.7270/Q2HD7WD6
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50711
PNG
(2-(2-carbomethoxy-4-hydroxy-6-methoxy-phenoxy)-6-h...)
Show SMILES COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(O)=O
Show InChI InChI=1S/C17H16O8/c1-8-4-11(19)14(16(20)21)12(5-8)25-15-10(17(22)24-3)6-9(18)7-13(15)23-2/h4-7,18-19H,1-3H3,(H,20,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Western Australia

Curated by ChEMBL


Assay Description
Displacement of endothelin-1 from ETA receptor in rat A10 cells


J Nat Prod 65: 7-10 (2002)


Article DOI: 10.1021/np0102758
BindingDB Entry DOI: 10.7270/Q2FB53VF
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034474
PNG
(4-Amino-N-(3-methyl-isoxazol-5-yl)-benzenesulfonam...)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1
Show InChI InChI=1S/C10H11N3O3S/c1-7-6-10(16-12-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6,13H,11H2,1H3
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n/an/a 2.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.


J Med Chem 38: 1344-54 (1995)


Article DOI: 10.1021/jm00008a013
BindingDB Entry DOI: 10.7270/Q20864BS
More data for this
Ligand-Target Pair