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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
Sodium- and chloride-dependent GABA transporter 1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
Ki: 72.4nM
Assay Description:
Displacement of [3H]Tiagabine from human recombinant GAT1 expressed in HEK293 cells by equilibrium binding assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Sodium- and chloride-dependent GABA transporter 1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibitory activity against human GABA transporter-1 (hGAT1)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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Target
Sodium- and chloride-dependent GABA transporter 1
(Rattus norvegicus)
Ludwig-Maximilians-University Munich
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
IC50: 692nM
Assay Description:
Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Sodium- and chloride-dependent GABA transporter 3
(Mus musculus)
Ludwig-Maximilians-University Munich
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
IC50: 1.95E+5nM
Assay Description:
Inhibition of mouse GAT3 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Sodium- and chloride-dependent GABA transporter 2
(Mus musculus)
Ludwig-Maximilians-University Munich
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
IC50: 3.72E+5nM
Assay Description:
Inhibition of mouse GAT2 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Sodium- and chloride-dependent GABA transporter 2
(Rattus norvegicus)
Synaptic Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
IC50: 5.50E+5nM
Assay Description:
Inhibitory activity against rat GABA transporter-2 (rGAT2)
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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CHEMBL
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In Depth
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Article
PubMed
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Target
Sodium- and chloride-dependent GABA transporter 3
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Copy InChI
Affinity Data
IC50: 1.99E+6nM
Assay Description:
Inhibitory activity against human sodium and chloride dependent GABA transporter 3
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Sodium- and chloride-dependent betaine transporter
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50020891
((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
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Affinity Data
IC50: 7.21E+6nM
Assay Description:
Inhibition of human GABA transporter (hBGT-1) activity.
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI