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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >3.00E+4nMAssay Description:Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloblastin(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Blockade of cathepsin G processing in human U937 cells by densitometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270039((S)-1-((1S,2S)-1-cyano-2-phenylcyclopropylamino)-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed