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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
4-hydroxyphenylpyruvate dioxygenase
(Homo sapiens (Human))
Central China Normal University
Curated by
ChEMBL
Ligand
BDBM50088804
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
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Affinity Data
Ki: 37nM
Assay Description:
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
DrugBank
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Target
4-hydroxyphenylpyruvate dioxygenase
(Rattus norvegicus)
Universit£
Curated by
ChEMBL
Ligand
BDBM50088804
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
4-hydroxyphenylpyruvate dioxygenase
(Rattus norvegicus)
Universit£
Curated by
ChEMBL
Ligand
BDBM50088804
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
Inhibition of Wistar rat liver HPPD using 4-Hydroxyphenylpyruvate as substrate assessed as reduction in oxygen consumption preincubated for 3 mins fo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
4-hydroxyphenylpyruvate dioxygenase
(Sus scrofa)
Tunghai Christian University
Curated by
ChEMBL
Ligand
BDBM50088804
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
Inhibition of 4-hydroxyphenylpyruvate dioxygenase of purified pig liver by enol-borate method
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI