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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by
ChEMBL
Ligand
BDBM50240895
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
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Affinity Data
Ki: 1.05E+5nM
Assay Description:
Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrulline
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Article
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Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM50240895
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
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Affinity Data
Ki: 1.05E+5nM
Assay Description:
Inhibition of rat recombinant nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of oxyhemoglobin to methemoglobin by UV spectro...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Nitric oxide synthase, endothelial
(Mus musculus)
Universit£
Curated by
ChEMBL
Ligand
BDBM50240895
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
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Affinity Data
Ki: >5.00E+6nM
Assay Description:
Inhibition of C57BL/6 mouse eNOS assessed as conversion of oxyhemoglobin to methemoglobin by UV spectrophotometer analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Aromatase
(Homo sapiens (Human))
Purdue University
Curated by
ChEMBL
Ligand
BDBM50240895
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of human aromatase preincubated with NADP+ for 10 mins before substrate addition measured after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Heme oxygenase 1
(Rattus norvegicus (rat))
University Of Catania
Curated by
ChEMBL
Ligand
BDBM50240895
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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CHEMBL
PC cid
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In Depth
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Article
PubMed
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Target
Heme oxygenase 2
(Rattus norvegicus (rat))
University Of Catania
Curated by
ChEMBL
Ligand
BDBM50240895
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI