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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
hits in this display
Target
Trypanothione reductase
(Trypanosoma cruzi)
Julius-Maximilians-University Of W£Rzburg
Curated by
ChEMBL
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
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Affinity Data
Ki: 400nM
Assay Description:
Competitive inhibition of Trypanosoma cruzi trypanothione reductase using varying levels of trypanothione disulfide as substrate by Lineweaver--burk ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Acetylcholinesterase
(Rattus norvegicus (rat))
Csir-Central Drug Research Institute
Curated by
ChEMBL
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
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Affinity Data
IC50: 0.770nM
Assay Description:
Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Acetylcholinesterase
(Rattus norvegicus (rat))
Csir-Central Drug Research Institute
Curated by
ChEMBL
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
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Copy InChI
Affinity Data
IC50: 0.770nM
pH: 7.4 T: 2°C
Assay Description:
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Acetylcholinesterase
(Rattus norvegicus (rat))
Csir-Central Drug Research Institute
Curated by
ChEMBL
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 31nM
Assay Description:
Inhibition of rat brain AChE
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Acetylcholinesterase
(Rattus norvegicus (rat))
Csir-Central Drug Research Institute
Curated by
ChEMBL
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 31nM
pH: 7.4 T: 2°C
Assay Description:
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carboxylic ester hydrolase
(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
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Affinity Data
IC50: 155nM
pH: 7.4 T: 2°C
Assay Description:
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carboxylic ester hydrolase
(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 155nM
Assay Description:
Inhibition of rat serum BuChE
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carboxylic ester hydrolase
(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 190nM
Assay Description:
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Carboxylic ester hydrolase
(Rattus norvegicus (rat))
Hong Kong University Of Science And Technology
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 190nM
Assay Description:
Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric meth...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cysteine protease
(Trypanosoma brucei rhodesiense)
Julius-Maximilians-University Of W£Rzburg
Curated by
ChEMBL
Ligand
BDBM10469
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
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Affinity Data
IC50: 1.94E+4nM
Assay Description:
Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 10 mins by spectrofluorometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI