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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  0.5nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  0.589nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  416nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes incubated for 60 mins in presence of [3H]-(+)-pentazocine by radioactivity metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  1.04E+4nMAssay Description:Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  1.08E+4nMAssay Description:Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed