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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
University Of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM34300(3-(1-benzotriazolylmethyl)-6-(phenylmethyl)-[1,2,4...)
Affinity DataIC50:  1.84E+3nMpH: 8.0 T: 2°CAssay Description:A fluorescence resonance energy transfer assay is developed in 96-well and 384-well microplate formats with robotic manipulation to enable high-throu...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM34300(3-(1-benzotriazolylmethyl)-6-(phenylmethyl)-[1,2,4...)
Affinity DataIC50:  1.94E+4nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM34300(3-(1-benzotriazolylmethyl)-6-(phenylmethyl)-[1,2,4...)
Affinity DataIC50:  4.88E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 11(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34300(3-(1-benzotriazolylmethyl)-6-(phenylmethyl)-[1,2,4...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay