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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
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Target
Neutrophil collagenase
(Homo sapiens (Human))
China Pharmaceutical University
Ligand
BDBM237180
((D-Pyr)-(D-Cys)-Bip-Arg)
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Affinity Data
IC50: 800nM
pH: 7.4 T: 2°C
Assay Description:
Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
China Pharmaceutical University
Ligand
BDBM237180
((D-Pyr)-(D-Cys)-Bip-Arg)
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Affinity Data
IC50: 2.75E+3nM
pH: 7.4 T: 2°C
Assay Description:
Recombinant human MMP-9 was expressed in Sf9 insect cells and purified by gelatin-Sepharose affinity chromatography as described previously16,17. It ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
China Pharmaceutical University
Ligand
BDBM237180
((D-Pyr)-(D-Cys)-Bip-Arg)
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Affinity Data
IC50: 4.75E+3nM
pH: 7.4 T: 2°C
Assay Description:
The activity of recombinant human MMP-3 (catalytic domain, Calbiochem) was detected with the substrate Mca-Arg-Pro-Lys-Pro-Val-Glu-Nval-Trp-Arg-Lys(D...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
China Pharmaceutical University
Ligand
BDBM237180
((D-Pyr)-(D-Cys)-Bip-Arg)
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Affinity Data
IC50: 5.50E+3nM
pH: 7.4 T: 2°C
Assay Description:
TACE was purchased as an active form enzyme (R&D Systems). Hydrolysis of the TACE-substrate Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH (s...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
KEGG
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI