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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  36.5nMpH: 7.4Assay Description:The HMGR activity was performed using HMG-CoA reductase assay kit from Sigma-Aldrich with the human recombinant protein or 100 μg total cell lys...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant HMG-CoA reductase (unknown origin) after 10 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  127nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  127nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  159nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  159nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  463nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  463nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of HMG-CoA reductase in human A549 cells after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed