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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50248067
(CHEMBL517760 | N-((1s,4R)-4-cyano-4-phenylcyclohex...)
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Affinity Data
IC50: 1.70nM
Assay Description:
Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus-infected Trichoplusia ni Hi5 cells assessed as reduction of [3H]cort...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50248067
(CHEMBL517760 | N-((1s,4R)-4-cyano-4-phenylcyclohex...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 62nM
Assay Description:
Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPH
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50248067
(CHEMBL517760 | N-((1s,4R)-4-cyano-4-phenylcyclohex...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 219nM
Assay Description:
Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albumin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI