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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 0.0470nM
Assay Description:
Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrs
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Target
Calcitonin gene-related peptide type 1 receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 0.0520nM
Assay Description:
Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells after 3 hrs
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Target
Isoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 0.640nM
Assay Description:
Displacement of [125I]amylin from human AMY1 receptor expressed in COS7 cells after 3 hrs
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Target
Calcitonin gene-related peptide type 1 receptor
(Rattus norvegicus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 17nM
Assay Description:
Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrs
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Target
Calcitonin gene-related peptide type 1 receptor
(Mus musculus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 19nM
Assay Description:
Displacement of [125I]CGRP from mouse CGRP receptor
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Target
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 3
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 590nM
Assay Description:
Displacement of [125I]adrenomedullin from human AM2 receptor expressed in HEK293 cells
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Target
Isoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 3
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 1.10E+3nM
Assay Description:
Displacement of [125I]amylin from human AMY3 receptor expressed in COS7 cells after 3 hrs
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Target
Isoform 1 of Calcitonin receptor (1)
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: 3.20E+3nM
Assay Description:
Displacement of [125I]calcitonin from human CT receptor expressed in HEK293 cells
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Target
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 2
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
Ki: >2.00E+4nM
Assay Description:
Displacement of [125I]adrenomedullin from human AM1 receptor expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
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Target
Calcitonin gene-related peptide type 1 receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.230nM
Assay Description:
Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence...
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Target
Calcitonin gene-related peptide type 1 receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.340nM
Assay Description:
Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presenc...
More data for this Ligand-Target Pair
Target Info
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of NaV1.5 ion channel by voltage clamp assay
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Target
Potassium voltage-gated channel subfamily E member 1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of Iks ion channel by voltage clamp assay
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50385309
(CHEMBL2035983)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CaV1.2 ion channel by voltage clamp assay
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