Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50:  270nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50:  2.30E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin E(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50:  1.76E+4nMpH: 5.5 T: 2°CAssay Description:A substrate peptide is labeled at the N-terminus with tryptophan and at the C-terminus with the fluorophore MR121 (for cathepsin D the 10 amino acid ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50:  2.11E+4nMpH: 5.5 T: 2°CAssay Description:A substrate peptide is labeled at the N-terminus with tryptophan and at the C-terminus with the fluorophore MR121 (for cathepsin D the 10 amino acid ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent