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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Neprilysin
(Rattus norvegicus (Rat))
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50034846
((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
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Affinity Data
IC50: 0.740nM
Assay Description:
The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Neprilysin
(Rattus norvegicus (Rat))
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50034846
((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
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Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Rattus norvegicus (Rat))
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50034846
((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.30nM
Assay Description:
The compound was tested in vitro for inhibition of neutral endopeptidase by using ANF(atrial natriuretic factor) as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Homo sapiens (Human))
Theravance Biopharma R&D Ip
US Patent
Ligand
BDBM50034846
((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
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Affinity Data
IC50: 27nM
Assay Description:
The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Neprilysin
(Rattus norvegicus (Rat))
Ciba-Geigy
Curated by
ChEMBL
Ligand
BDBM50034846
((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 700nM
Assay Description:
In vitro inhibition of rat neutral endopeptidase by using GAAP as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin/Angiotensin-converting enzyme
(Homo sapiens (Human))
Theravance Biopharma R&D Ip
US Patent
Ligand
BDBM50034846
((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
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Copy InChI
Affinity Data
IC50: 700nM
Assay Description:
NEP inhibitors, such as thiorphan, candoxatril, and candoxatrilat, have been studied as potential therapeutics. Compounds that inhibit both NEP and a...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI