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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
17
hits in this display
Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
Ki: 2.00E+4nM
Assay Description:
Compound was evaluated for its binding affinity to CHO cells expressing the cloned human Beta-3 adrenergic receptor in the presence of [125I]iodocyan...
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
Ki: 7.92E+4nM
Assay Description:
Inhibition of I-iodocyanopindolol binding to human beta 2 adrenergic receptors
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of I-iodocyanopindolol binding to human beta 1 adrenergic receptors
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
IC50: 9.77E+3nM
Assay Description:
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos...
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
IC50: 2.70E+5nM
Assay Description:
Compound was evaluated for its binding affinity towards Beta-2 adrenergic receptor in rat soleus membrane by displacing (-)-isoproterenol (50 microM)
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
IC50: 1.30E+6nM
Assay Description:
Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysis
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Target
Beta-3 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
EC50: 25.1nM
Assay Description:
Agonistic activity towards beta-3 adrenoceptor. Mean concentration required to produce 50% relaxation of detrusor before the addition in the ferret d...
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human))
American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
EC50: >1.00E+6nM
Assay Description:
Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
EC50: 1.11E+5nM
Assay Description:
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
EC50: 1.15E+3nM
Assay Description:
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-3-andrenergic receptor
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PubMed
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
EC50: 2.62E+5nM
Assay Description:
Agonistic activity was assessed by measurement of cAMP accumulation levels in CHO cells expressing human beta-2-adrenergic receptor
More data for this Ligand-Target Pair
Target Info
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Target
Beta-3 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
EC50: 3nM
Assay Description:
Compound was evaluated in vitro for beta-adrenergic activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol...
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM25763
(5-[(2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
Kd: 7.76E+3nM
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002134
(5-((2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
Copy SMILES
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Affinity Data
EC50: 220nM
Assay Description:
Agonist activity at Homo sapiens (human) beta3 adrenoreceptor
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM25763
(5-[(2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
Kd: >1.00E+6nM
pH: 7.4 T: 2°C
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
More data for this Ligand-Target Pair
Target Info
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM25763
(5-[(2R)-2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl...)
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Affinity Data
Kd: 7.94E+4nM
Assay Description:
The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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PC cid
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