Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM25521(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Affinity DataIC50:  207nMpH: 7.2 T: 2°CAssay Description:An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM25521(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Affinity DataIC50:  2.17E+3nMpH: 7.2 T: 2°CAssay Description:An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM25521(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Affinity DataIC50:  6.28E+3nMAssay Description:The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled peptide substrate and Mg(or Mn)/ATP. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM25521(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Affinity DataIC50:  6.80E+3nMAssay Description:The activity was determined by IMAP assay. The enzyme was incubated with fluorescein labeled peptide and phosphorylation was detected by IMAP technol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM25521(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 2°CAssay Description:An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed