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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  47nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  460nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  580nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  1.57E+4nMAssay Description:Inhibition of JAK3 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of JAK3 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataEC50:  20nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed