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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
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Affinity Data
IC50: <3nM
Assay Description:
Inhibition of JAK2 using 2 mM ATP as a substrate
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 87nM
Assay Description:
Inhibition of JAK2 using 5 mM ATP as a substrate
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
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Copy InChI
Affinity Data
IC50: 410nM
Assay Description:
Inhibition of CDK2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aurora kinase B
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
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Copy InChI
Affinity Data
IC50: 850nM
Assay Description:
Inhibition of Aurora B
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
High affinity nerve growth factor receptor
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
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Copy InChI
Affinity Data
IC50: 1.48E+3nM
Assay Description:
Inhibition of TRKA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase JAK3
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.65E+4nM
Assay Description:
Inhibition of JAK3 using 5 mM ATP as a substrate
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Signal transducer and activator of transcription 5B
(Homo sapiens (Human))
Astrazeneca R&D Boston
Curated by
ChEMBL
Ligand
BDBM50303042
((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
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Copy InChI
Affinity Data
EC50: 40nM
Assay Description:
Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI