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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
2
hits in this display
Target
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
(Homo sapiens (Human))
Forma Therapeutics
US Patent
Ligand
BDBM317530
(6-chloro-3-[(1S)-1-({1H-pyrazolo[3,4-d]pyrimidin-6...)
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Affinity Data
IC50: 550nM
Assay Description:
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Isocitrate dehydrogenase [NADP] cytoplasmic [1-390,401-414,R132C]
(Homo sapiens (Human))
Forma Therapeutics
US Patent
Ligand
BDBM317530
(6-chloro-3-[(1S)-1-({1H-pyrazolo[3,4-d]pyrimidin-6...)
Copy SMILES
Affinity Data
IC50: 5.50E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI