Home
About
Info
Download
WebServices
Contact
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
2
hits in this display
Target
Isocitrate dehydrogenase [NADP] cytoplasmic
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM146092
(US8957068, 127)
Copy SMILES
Copy InChI
Affinity Data
IC50: 158nM
pH: 7.4 T: 2°C
Assay Description:
Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Isocitrate dehydrogenase [NADP] cytoplasmic
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM146092
(US8957068, 127)
Copy SMILES
Copy InChI
Affinity Data
IC50: 215nM
pH: 7.5 T: 2°C
Assay Description:
The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI