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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130171((S)-1-[(4S,6R)-4-(4-Fluoro-benzo[b]thiophen-2-yl)-...)
Affinity DataKi:  1.20nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130171((S)-1-[(4S,6R)-4-(4-Fluoro-benzo[b]thiophen-2-yl)-...)
Affinity DataKi:  4.90nMAssay Description:Inhibition of 5-HT induced [35S]-GTP-gammaS, binding at human cloned 5-HT 1A receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130171((S)-1-[(4S,6R)-4-(4-Fluoro-benzo[b]thiophen-2-yl)-...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 1A receptor by [3H]-8-OH-DPAT displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed