Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

US Patent

LigandBDBM336562(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6- | US...)Copy SMILESCopy InChI

Affinity DataIC50:  2.11E+3nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetIsoform D of Beta-secretase 1 (BACE-I-432)(Homo sapiens (Human))
Pfizer

US Patent

LigandBDBM223425(US9315520, 68)Copy SMILESCopy InChI

Affinity DataIC50:  2.11E+3nMpH: 4.5 T: 2°CAssay Description:The substrate is Biotin-GLTNIKTEEISEISY^EVEFR-C[Oregon Green]KK-OH. The BACE1 enzyme is affinity purified material from conditioned media of CHO-K1 c...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI