Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen

LigandBDBM32574(arylsulfonylpiperazine, 46)Copy SMILESCopy InChI

Affinity DataIC50:  29nM EC50:  527nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen

LigandBDBM32574(arylsulfonylpiperazine, 46)Copy SMILESCopy InChI

Affinity DataIC50:  37nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI