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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Coagulation factor VII/Tissue factor
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 0.160nM
Assay Description:
Inhibition of human TF-factor 7a (366 to 11 residues) using factor 10 as substrate after 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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Article
PubMed
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Target
Coagulation factor VII/Tissue factor
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 0.160nM
Assay Description:
Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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In Depth
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Article
PubMed
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Target
Coagulation factor VII
(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 0.170nM
Assay Description:
FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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In Depth
Details
US Patent
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Target
Coagulation factor VII
(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 270nM
pH: 7.4
Assay Description:
Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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US Patent
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Target
Kallikrein-1
(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by
ChEMBL
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 270nM
Assay Description:
Inhibition of human HK1 using H-D-Val-Leu-Arg-AFC as substrate assessed as release of AFC after 10 to 120 mins by spectrofluorimetric method
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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In Depth
Details
Article
PubMed
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Target
Coagulation factor X
(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by
ChEMBL
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 1.80E+3nM
Assay Description:
Inhibition of human factor 10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectroph...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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In Depth
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Article
PubMed
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Target
Coagulation factor XI
(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by
ChEMBL
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 2.30E+3nM
Assay Description:
Inhibition of human factor 11a using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Prothrombin
(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by
ChEMBL
Ligand
BDBM189445
(US9174974, Example 31)
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Affinity Data
Ki: 3.80E+3nM
Assay Description:
Inhibition of alpha-thrombin (unknown origin) using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotom...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI