Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50252736(CHEMBL522877 | N-Cyclopropyl-6-methyl-7-(1-((S)-3-...)Copy SMILESCopy InChI

Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50252736(CHEMBL522877 | N-Cyclopropyl-6-methyl-7-(1-((S)-3-...)Copy SMILESCopy InChI

Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50252736(CHEMBL522877 | N-Cyclopropyl-6-methyl-7-(1-((S)-3-...)Copy SMILESCopy InChI

Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI