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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
37
hits in this display
Target
DNA topoisomerase 2-beta
(Homo sapiens (Human))
Kansas University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
Ki: 2.49E+3nM
Assay Description:
Binding affinity against sigma receptor
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Target
DNA topoisomerase 2-beta
(Homo sapiens (Human))
Kansas University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
Ki: 9.96E+4nM
Assay Description:
Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperone
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Target
DNA gyrase subunit A/B
(Escherichia coli (strain K12))
Wakunaga Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 470nM
Assay Description:
Inhibition of Escherichia coli DNA gyrase preincubated for 5 mins at 37 degC before addition of relaxed pBR322 as substrate by supercoiling assay
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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
(Rattus norvegicus)
Peking University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 18 hrs by broth microdilution method
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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
(Rattus norvegicus)
Peking University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Antibacterial activity against vancomycin-sensitive Enterococcus faecalis 12-5 after 18 hrs by broth microdilution method
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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
(Rattus norvegicus)
Peking University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 after 18 hrs by broth microdilution method
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Target
DNA topoisomerase 2-beta
(Homo sapiens (Human))
Kansas University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 2.76E+3nM
Assay Description:
Gyrase inhibitory activity against Escherichia coli
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 8.85E+3nM
Assay Description:
Inhibitory activity against wild type gyrase in Escherichia coli
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Target
DNA topoisomerase 4 subunit A/B
(Staphylococcus aureus)
Sapienza University Of Rome
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 1.02E+4nM
Assay Description:
Inhibition of Staphylococcus aureus topoisomerase-4 expressed in Escherichia coli assessed as relaxation of pBR322 substrate measured after 4 hrs by ...
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 1.79E+4nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
DNA gyrase subunit A/B
(Staphylococcus aureus)
Kyorin Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 2.57E+4nM
Assay Description:
Inhibition of Staphylococcus aureus MS5935 wild type DNA gyrase-mediated supercoiling activity
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Target
DNA gyrase subunit A/B
(Staphylococcus aureus)
Kyorin Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 2.60E+4nM
Assay Description:
Inhibition of Staphylococcus aureus wild type DNA gyrase
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 3.59E+4nM
Assay Description:
Inhibitory activity against quinolone resistant gyrase in Escherichia coli
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Target
DNA primase
(Bacillus anthracis (Firmicutes))
University Of Michigan
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 7.50E+4nM
pH: 8.8
Assay Description:
The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP...
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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
(Rattus norvegicus)
Peking University
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.28E+5nM
Assay Description:
Antibacterial activity against vancomycin-resistant Enterococcus faecalis 09-9 after 18 hrs by broth microdilution method
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
DNA gyrase subunit A/B
(Staphylococcus aureus)
Kyorin Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 5.45E+5nM
Assay Description:
Inhibition of Staphylococcus aureus DNA gyrase S84L mutant
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 9.12E+5nM
Assay Description:
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 9.12E+5nM
Assay Description:
Inhibitory concentration against potassium channel HERG
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 9.12E+5nM
Assay Description:
Inhibition of human Potassium channel HERG expressed in mammalian cells
More data for this Ligand-Target Pair
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Copy SMILES
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Affinity Data
IC50: 9.15E+5nM
Assay Description:
Inhibition of human ERG current by patch clamp assay
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 1.10E+6nM
Assay Description:
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by pa...
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Target
DNA gyrase subunit A
(Staphylococcus aureus)
Daiichi Sankyo
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.41E+6nM
Assay Description:
Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: >1.66E+6nM
Assay Description:
Inhibitory activity against mammalian DNA topoisomerase II
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 2.10E+6nM
Assay Description:
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...
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Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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Target
DNA gyrase subunit A/B
(Staphylococcus aureus)
Kyorin Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 2.13E+6nM
Assay Description:
Inhibition of quinoline-resistant Staphylococcus aureus MS5935 DNA gyrase-mediated supercoiling activity
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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ChEBI
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MCE
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PubMed
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
IC50: 2.30E+6nM
Assay Description:
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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MCE
KEGG
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PC sid
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Article
PubMed
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30E+6nM
Assay Description:
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
DrugBank
MCE
KEGG
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PC sid
PDB
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+6nM
Assay Description:
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
DrugBank
MCE
KEGG
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PC sid
PDB
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+6nM
Assay Description:
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
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PC sid
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PubMed
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50366826
(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
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Affinity Data
EC50: >2.80E+5nM
Assay Description:
Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation method
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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MCE
KEGG
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Copy BDB DOI