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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetAcetylcholinesterase(Homo sapiens (Human))
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division protein FtsZ(Bacillus subtilis)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of FtsZ in Bacillus subtilis assessed as disruption of Z ring formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  7.08E+3nMAssay Description:Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRegulator of G-protein signaling 17(Homo sapiens)
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of RGS17 (unknown origin) GAP activity in presence of GTP by malachite green dye based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division protein FtsZ(Escherichia coli)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of FtsZ in Escherichia coli assessed as disruption of Z ring formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
A* Star

LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  1.90E+4nMpH: 8.0 T: 2°CAssay Description:In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibrinogen beta chain [164-491](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  2.42E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Harvard Medical School/Massachuset...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup 3 secretory phospholipase A2(Homo sapiens)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  5.18E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))
Exonhit Therapeutics

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRegulator of G-protein signaling 17(Homo sapiens)
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  7.28E+4nMAssay Description:Inhibition of wild type GST-tagged RGS17 (unknown origin) interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibrinogen beta chain [164-491](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  8.31E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Harvard Medical School/Massachuset...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRegulator of G-protein signaling 17(Homo sapiens)
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of RGS17 (unknown origin) C117A mutant interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatic-L-amino-acid decarboxylase(Homo sapiens (Human))
Hunan Agricultural University

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
University Of Allahabad

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  3.82E+5nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50: <4.51E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRegulator of G-protein signaling 17(Homo sapiens)
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to RGS17 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed