Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50443650(CHEMBL3093074)Copy SMILESCopy InChI

Affinity DataIC50:  1nMAssay Description:Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50443650(CHEMBL3093074)Copy SMILESCopy InChI

Affinity DataIC50:  71nMAssay Description:Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50443650(CHEMBL3093074)Copy SMILESCopy InChI

Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI