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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
18
hits in this display
Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Targacept
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
Ki: 29nM
Assay Description:
Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand
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Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
Ki: 30nM
Assay Description:
Affinity at alpha4-beta2 nACh receptors in rat brain (minus cerebellum) homogenates.
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
Ki: 30nM
Assay Description:
Binding affinity for rat brain Nicotinic acetylcholine receptor alpha4-beta2 using [3H]S-(-)-nicotine
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Target Info
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MMDB
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50035415
((S)-1'-demethylnicotine | 1'-demethyl nicotine | 3...)
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Affinity Data
Ki: 33nM
Assay Description:
Binding affinity towards alpha4-beta2 measured by using the inhibition of [3H]NIC binding to rat striatal membrane
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-2
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50035415
((S)-1'-demethylnicotine | 1'-demethyl nicotine | 3...)
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Affinity Data
Ki: 47nM
Assay Description:
Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranes
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Targacept
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
Ki: 730nM
Assay Description:
Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50035415
((S)-1'-demethylnicotine | 1'-demethyl nicotine | 3...)
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Affinity Data
Ki: 1.19E+3nM
Assay Description:
Binding affinity towards alpha-7 neuronal nicotonic acetylcholine receptor (nAChRs) measured by using the inhibition of [3H]-MLA binding to whole bra...
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50035415
((S)-1'-demethylnicotine | 1'-demethyl nicotine | 3...)
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Affinity Data
Ki: 1.34E+3nM
Assay Description:
Affinity for alpha-7 neuronal nicotinic acetylcholine receptor subtype determined by inhibition of [3H]-MLA binding to rat brain membranes
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Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Targacept
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
Ki: 1.38E+5nM
Assay Description:
Binding affinity for nicotinic acetylcholine receptor alpha 7 from human neuroblastoma SH-SY5Y cells; n=3
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Target Info
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Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica)
Stauffer Chemical
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
IC50: 100nM
Assay Description:
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes
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Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica)
Stauffer Chemical
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of [3H]-MCC binding to rat brain membranes
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Target
Cytochrome P450 2A6
(Homo sapiens (Human))
Human Biomolecular Research Institute
US Patent
Ligand
BDBM50035415
((S)-1'-demethylnicotine | 1'-demethyl nicotine | 3...)
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Affinity Data
IC50: >4.00E+5nM
Assay Description:
The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...
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Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
EC50: 3.75E+5nM
Assay Description:
Agonist activity at rat alpha4beta2 nAChR expressed in Xenopus laevis oocytes
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Rattus norvegicus (Rat))
University Of Auckland
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
EC50: 6.14E+5nM
Assay Description:
Agonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Resistance to inhibitors of cholinesterase protein 3
(Pig roundworm)
Iowa State University Research Foundation
US Patent
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
EC50: 2.57E+4nM
Assay Description:
Nematode eggs are isolated from fresh feces by centrifugation and flotation. The eggs are washed and inspected to confirm embryonation has not starte...
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Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Targacept
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
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Affinity Data
Kd: 1.06nM
Assay Description:
Dissociation constant for nicotinic acetylcholine receptor alpha 7 from human neuroblastoma SH-SY5Y cells; n=3
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.74E+4nM
Assay Description:
Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
(S)-6-hydroxynicotine oxidase
(Arthrobacter nicotinovorans)
University of Texas At San Antonio
Ligand
BDBM181055
((S)-nornicotine)
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Affinity Data
Kd: 4.60E+6nM
pH: 8.0
Assay Description:
Initial rates of amine oxidation were routinely measured by monitoring oxygen consumption in 0.1 M Hepes (pH 8.0) and 0.1 M NaCl at 25 °C using an ox...
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Target Info
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