Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q]
(Homo sapiens (Human))
Vertex Pharmaceuticals
Ligand
BDBM26545
(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 55nM ΔG°: -41.0kJ/mole
pH: 7.5 T: 2°C
Assay Description:
The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Vertex Pharmaceuticals
Ligand
BDBM26545
(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 90nM ΔG°: -39.8kJ/mole
pH: 7.4 T: 2°C
Assay Description:
A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Vertex Pharmaceuticals
Ligand
BDBM26545
(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 700nM ΔG°: -34.8kJ/mole
pH: 7.4 T: 2°C
Assay Description:
A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neutrophil collagenase
(Homo sapiens (Human))
Vertex Pharmaceuticals
Ligand
BDBM26545
(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 800nM ΔG°: -34.4kJ/mole
pH: 7.4 T: 2°C
Assay Description:
A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Vertex Pharmaceuticals
Ligand
BDBM26545
(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >3.00E+3nM ΔG°: >-31.2kJ/mole
pH: 7.4 T: 2°C
Assay Description:
A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI