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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Nuclear receptor ROR-gamma
(Homo sapiens (Human))
Genentech
US Patent
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
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Affinity Data
IC50: 30nM
pH: 7.4
Assay Description:
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
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In Depth
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US Patent
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Target
Nuclear receptor ROR-gamma
(Homo sapiens (Human))
Genentech
US Patent
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
Copy SMILES
Copy InChI
Affinity Data
EC50: 270nM
Assay Description:
Agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
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Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Nuclear receptor ROR-beta
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
Copy SMILES
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at GAL4-fused human RORb expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
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Article
PubMed
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Target
Bile acid receptor
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at GAL4-fused human FXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...
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Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Oxysterols receptor LXR-alpha
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
Copy SMILES
Copy InChI
Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at GAL4-fused human LXRalpha expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dua...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Oxysterols receptor LXR-beta
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
Copy SMILES
Copy InChI
Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Nuclear receptor ROR-gamma
(Homo sapiens (Human))
Genentech
US Patent
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
Copy SMILES
Copy InChI
Affinity Data
EC50: 13nM
Assay Description:
Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Nuclear receptor ROR-alpha
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50050117
(CHEMBL3317843 | US9216988, 54)
Copy SMILES
Copy InChI
Affinity Data
EC50: >1.00E+4nM
Assay Description:
Inverse agonist activity at GAL4-fused human RORa expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI