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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
hits in this display
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
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Affinity Data
Ki: 87nM
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.30E+3nM
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 100nM
Assay Description:
Inhibition of human recombinant COX2 after 5 mins
More data for this Ligand-Target Pair
Target Info
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 102nM
Assay Description:
Inhibitory activity against cell-free canine COX-2
More data for this Ligand-Target Pair
Target Info
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 102nM
Assay Description:
Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Copy BDB DOI
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50397558
(CARPROFEN | CHEMBL2171249)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.30E+3nM
Assay Description:
Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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ChEBI
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia
Curated by
ChEMBL
Ligand
BDBM50397558
(CARPROFEN | CHEMBL2171249)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.60E+3nM
Assay Description:
Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
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ChEBI
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Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.30E+4nM
Assay Description:
Inhibition of ovine COX1 after 5 mins
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
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B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
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PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.32E+4nM
Assay Description:
Inhibitory activity against cell-free canine COX-1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
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MCE
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.32E+4nM
Assay Description:
Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
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Ligand Info
Purchase
ChEBI
CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.23E+4nM
Assay Description:
Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
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B.MOAD
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Purchase
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Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
University Of Cagliari
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.20E+4nM
Assay Description:
Inhibition of rat brain FAAH using [3H]AEA as substrate
More data for this Ligand-Target Pair
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3D Structure (crystal)
Copy BDB DOI
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80E+4nM
Assay Description:
Inhibition of COX2 in human whole blood
More data for this Ligand-Target Pair
Target Info
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KEGG
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Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.90E+4nM
Assay Description:
Inhibition of COX1 in human whole blood
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
University Of Cagliari
Curated by
ChEMBL
Ligand
BDBM50397558
(CARPROFEN | CHEMBL2171249)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.42E+4nM
Assay Description:
Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid ...
More data for this Ligand-Target Pair
Target Info
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ChEBI
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3D Structure (crystal)
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
University Of Cagliari
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.86E+4nM
Assay Description:
Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid ...
More data for this Ligand-Target Pair
Target Info
PDB
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3D Structure (crystal)
Copy BDB DOI
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM50397557
(CARPROFEN | CHEMBL2171250)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
University Of Cagliari
Curated by
ChEMBL
Ligand
BDBM50397557
(CARPROFEN | CHEMBL2171250)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
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In Depth
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PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Istituto Italiano Di Tecnologia
Curated by
ChEMBL
Ligand
BDBM50397557
(CARPROFEN | CHEMBL2171250)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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Purchase
ChEBI
CHEMBL
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PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
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ChEBI
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
More data for this Ligand-Target Pair
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
Copy SMILES
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
More data for this Ligand-Target Pair
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Target
Complement C5
(Homo sapiens)
Indian Institute Of Technology Bhubaneswar
Curated by
ChEMBL
Ligand
BDBM50097346
((+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid ...)
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Affinity Data
Kd: 580nM
Assay Description:
Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis
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