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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 5 mins by ELISA in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 1 hr by ELISA in a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  8nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Rattus norvegicus)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  10nMAssay Description:Inhibition of FLAP in rat whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  12nMAssay Description:Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 3 hr by ELISA in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  66nMAssay Description:Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  80nMAssay Description:Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 11 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  108nMAssay Description:Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Rattus norvegicus)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  117nMAssay Description:Inhibition of FLAP in rat whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052018(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)
Affinity DataIC50:  536nMAssay Description:Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed