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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Discoidin domain-containing receptor 2
(Homo sapiens (Human))
Technical University Of Dortmund
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 558nM
Assay Description:
Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Article
PubMed
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Putative glycogen synthase kinase 3 alpha
(Ustilago maydis (Smut fungus))
Technische UniversitÄT Dortmund
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 7.80E+3nM
Assay Description:
Inhibition of UmGSK3 by kinase inhibitors.
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M]
(Gallus gallus (Chicken))
Chemical Genomics Centre Of The Max Planck Society
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 2.78E+4nM
pH: 7.0 T: 2°C
Assay Description:
IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken))
Chemical Genomics Centre Of The Max Planck Society
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 3.21E+4nM
pH: 7.0 T: 2°C
Assay Description:
IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken))
Chemical Genomics Centre Of The Max Planck Society
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: 3.21E+4nM
Assay Description:
Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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PC sid
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Article
PubMed
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Technische UniversitÄT Dortmund
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of UmGSK3 by kinase inhibitors.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Technische UniversitÄT Dortmund
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of human GSK-3beta using Ser/Thr 6 peptide as substrate preincubated for 60 mins followed by ATP and substrate addition and measured after...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
Kd: 55nM
Assay Description:
Binding affinity to p38alpha
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Discoidin domain-containing receptor 2
(Homo sapiens (Human))
Technical University Of Dortmund
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Affinity Data
Kd: 15nM
Assay Description:
Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Discoidin domain-containing receptor 2
(Homo sapiens (Human))
Technical University Of Dortmund
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
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Copy InChI
Affinity Data
Kd: 3.80nM
Assay Description:
Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by fluorescence spectroscopy
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 55nM
Assay Description:
Serine/threonine kinase inhibition assay using MAP p38 alpha fluorescence-labeled approach.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Discoidin domain-containing receptor 2
(Homo sapiens (Human))
Technical University Of Dortmund
Curated by
ChEMBL
Ligand
BDBM31824
(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 15nM
Assay Description:
Binding affinity to human DDR2 by Ambit assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI