Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University

Curated by ChEMBL

LigandBDBM50353678(CHEMBL1830338)Copy SMILESCopy InChI

Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University

Curated by ChEMBL

LigandBDBM50353678(CHEMBL1830338)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Gazi University

Curated by ChEMBL

LigandBDBM50353678(CHEMBL1830338)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 12-Lipoxygenase-mediated 12-HETE in human neutrophil after 15 mins by HPLC analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Gazi University

Curated by ChEMBL

LigandBDBM50353678(CHEMBL1830338)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 15-Lipoxygenase-mediated 15-HETE in human neutrophil after 15 mins by HPLC analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Gazi University

Curated by ChEMBL

LigandBDBM50353678(CHEMBL1830338)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Gazi University

Curated by ChEMBL

LigandBDBM50353678(CHEMBL1830338)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COX2-mediated 6-keto PGF1alpha production in IL1-beta stimulated human A549 cells after 10 mins by EIAMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI