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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
23
hits in this display
Target
Mitogen-activated protein kinase kinase kinase 5
(Homo sapiens (Human))
Pharmadesign
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of ASK1 assessed as phosphorylated fluorescent peptide by mobility shift assay
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3D Structure (crystal)
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Target
Mitogen-activated protein kinase kinase kinase 5
(Homo sapiens (Human))
Pharmadesign
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 14nM
Assay Description:
Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation co...
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Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 155nM
Assay Description:
In vitro inhibition of porcine Dipeptidylpeptidase II.
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Target
Mitogen-activated protein kinase kinase kinase 6
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 510nM
Assay Description:
Inhibition of ASK2
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 832nM
Assay Description:
Inhibition of recombinant full length human His-tagged GSK3B expressed in baculovirus expression system
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Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 4.90E+3nM
Assay Description:
Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression system
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Target
Tyrosine-protein kinase ITK/TSK
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 5.50E+3nM
Assay Description:
Inhibition of recombinant full length human GST-tagged ITK expressed in baculovirus expression system
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Target
Tyrosine-protein kinase Mer
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 6.46E+3nM
Assay Description:
Inhibition of recombinant human GST-tagged MER cytoplasmic domain expressed in baculovirus expression system
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Target
Nuclear receptor subfamily 2 group C member 2
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of TAK1
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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of IKKbeta
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Target
Mitogen-activated protein kinase 3
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of ERK1
More data for this Ligand-Target Pair
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Target
Mitogen-activated protein kinase 8
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of JNK1
More data for this Ligand-Target Pair
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Target
Mitogen-activated protein kinase kinase kinase 1
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of MEKK1
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Target
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of BRAF
More data for this Ligand-Target Pair
Target Info
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Target
Protein kinase C theta type
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of PKCtheta
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
Copy SMILES
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of GSK3beta
More data for this Ligand-Target Pair
Target Info
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of p38alpha
More data for this Ligand-Target Pair
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Target
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 1.15E+4nM
Assay Description:
Inhibition of recombinant human GST-tagged RET cytoplasmic domain expressed in baculovirus expression system
More data for this Ligand-Target Pair
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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: 1.38E+4nM
Assay Description:
Inhibition of PRKAA1 (unknown origin)
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Target
Receptor tyrosine-protein kinase erbB-4
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: <2.00E+4nM
Assay Description:
Inhibition of recombinant human N-terminal GST-tagged ERBB4 cytoplasmic domain (708 to 993 residues) expressed in baculovirus expression system
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Target
Macrophage-stimulating protein receptor
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: <2.00E+4nM
Assay Description:
Inhibition of recombinant human GST-tagged RON cytoplasmic domain expressed in baculovirus expression system
More data for this Ligand-Target Pair
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Target
Ephrin type-A receptor 3
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: <2.00E+4nM
Assay Description:
Inhibition of recombinant human His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression system
More data for this Ligand-Target Pair
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Takeda California
Curated by
ChEMBL
Ligand
BDBM50334268
(CHEMBL1642655 | CHEMBL2205637 | N-(6-(1H-imidazol-...)
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Affinity Data
IC50: <2.00E+4nM
Assay Description:
In vitro inhibition of human Dipeptidylpeptidase IV.
More data for this Ligand-Target Pair
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