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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50:  3nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50:  56nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50:  220nMAssay Description:Binding affinity to mineralocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50:  1.90E+3nMAssay Description:Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataEC50:  45nMAssay Description:Transactivation activity at glucocorticoid receptor in HFF assessed as induction of aromatase activity after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed