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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
32
hits in this display
Target
Muscarinic acetylcholine receptor
(RABBIT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
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Affinity Data
Ki: 0.130nM
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
Ki: 0.190nM
Assay Description:
Antagonist activity at human recombinant M3 receptor expressed in CHO-K1 cells assessed as inhibition of carbamoyl choline-induced calcium currents a...
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Target
Muscarinic acetylcholine receptor M4
(Chick)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
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Affinity Data
Ki: 0.210nM
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Copy InChI
Affinity Data
Ki: 0.213nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M3 receptor expressed in CHO cells after 24 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.290nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M3 receptor expressed in CHO cells after 2 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
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Affinity Data
Ki: 0.360nM
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Target
Muscarinic acetylcholine receptor M3
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
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Affinity Data
Ki: 0.370nM
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
Ki: 0.382nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M4 receptor expressed in CHO cells after 24 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.413nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
Copy SMILES
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Affinity Data
Ki: 0.433nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M1 receptor expressed in CHO cells after 24 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.480nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
Copy SMILES
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Affinity Data
Ki: 0.490nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.510nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.660nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
Copy SMILES
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Affinity Data
Ki: 0.710nM
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50581210
(IPRATROPIUM | Ipratropium | Ipratropium cation | I...)
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Affinity Data
Ki: 0.794nM
Assay Description:
Displacement of [3H]-N-methyl Scopolamine Chloride from human M3 receptor membranes incubated for 2 hrs by scintillation counting analysis
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50581210
(IPRATROPIUM | Ipratropium | Ipratropium cation | I...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.794nM
Assay Description:
Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50378083
(Atrovent HFA | IPRATROPIUM BROMIDE)
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Affinity Data
Ki: 0.830nM
Assay Description:
Binding affinity to muscarinic M3 receptor
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50378083
(Atrovent HFA | IPRATROPIUM BROMIDE)
Copy SMILES
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Affinity Data
Ki: 1.02nM
Assay Description:
Binding affinity to muscarinic M2 receptor
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
Ki: 1.04nM
Assay Description:
Displacement of [3H]-NMS from human recombinant M5 receptor expressed in CHO cells after 24 hrs by filter binding assay
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.5nM
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50378083
(Atrovent HFA | IPRATROPIUM BROMIDE)
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Affinity Data
Ki: 1.51nM
Assay Description:
Binding affinity to muscarinic M1 receptor
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM82372
(CAS_22254-24-6 | Ipratropium | NSC_3746)
Copy SMILES
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Affinity Data
Ki: 1.70nM
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50378083
(Atrovent HFA | IPRATROPIUM BROMIDE)
Copy SMILES
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Affinity Data
IC50: 2.07nM
Assay Description:
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation counting
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50378083
(Atrovent HFA | IPRATROPIUM BROMIDE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.24nM
Assay Description:
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50378083
(Atrovent HFA | IPRATROPIUM BROMIDE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.65nM
Assay Description:
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation counting
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM228865
(Ipratropium | US9333195, IPRATROPIUM)
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Affinity Data
IC50: 3nM
Assay Description:
The binding of [3H]-NMS to human muscarinic receptors was performed according to Waelbroek et al (1990) (1). Assays were carried out at 25° C. Membra...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM228865
(Ipratropium | US9333195, IPRATROPIUM)
Copy SMILES
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Affinity Data
IC50: 3nM
T: 2°C
Assay Description:
Assays were carried out at 25° C. Membrane preparations from stably transfected chinese hamster ovary-K1 cells (CHO) expressing the genes for the...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50355610
(CHEMBL1237108)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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