Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.770nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.770nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.770nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.770nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.770nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.770nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  380nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  380nMAssay Description:Inhibition of PKG2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of GSK3A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed