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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
Ki: 0.0390nM
Assay Description:
Binding affinity to human KISS1R expressed in CHO cell membranes
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Target
KiSS-1 receptor
(Rattus norvegicus)
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
Ki: 0.0570nM
Assay Description:
Binding affinity to rat KISS1R
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [125]metastin from metastin receptor
More data for this Ligand-Target Pair
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Copy InChI
Affinity Data
IC50: 0.0820nM
Assay Description:
Binding affinity to human KISS1R
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
GoogleScholar
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CHEMBL
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Article
PubMed
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Target
KiSS-1 receptor
(Rattus norvegicus)
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
IC50: 0.110nM
Assay Description:
Binding affinity to rat KISS1R
More data for this Ligand-Target Pair
Target Info
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
IC50: 0.120nM
pH: 7.3 T: 2°C
Assay Description:
Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...
More data for this Ligand-Target Pair
Target Info
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
IC50: 0.120nM
Assay Description:
Displacement of [125I]kisspeptin-15 from GPR54
More data for this Ligand-Target Pair
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Target
Neuropeptide FF receptor 1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
IC50: 4.70nM
Assay Description:
Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrs
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Target
Neuropeptide FF receptor 2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
IC50: 76nM
Assay Description:
Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR2 after 2 hrs
More data for this Ligand-Target Pair
Target Info
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
IC50: 8.51E+3nM
Assay Description:
Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay
More data for this Ligand-Target Pair
Target Info
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KEGG
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CHEMBL
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Article
PubMed
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Affinity Data
EC50: 0.0650nM
Assay Description:
Agonist activity at human OT7T175 assessed as increase in intracellular calcium level by FLIPR assay
More data for this Ligand-Target Pair
Target Info
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KEGG
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
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Copy InChI
Affinity Data
EC50: 17.3nM
Assay Description:
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
More data for this Ligand-Target Pair
Target Info
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KEGG
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GoogleScholar
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
KiSS-1 receptor
(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM26349
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 0.0490nM
Assay Description:
Agonist activity at human KISS1R assessed as induction of intracellular calcium mobilization by fluorometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI