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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
2
hits in this display
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50344415
(CHEMBL1779844 | N-Isopropyl-6-phenylethynyl-nicoti...)
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Affinity Data
Ki: 7.10E+3nM
Assay Description:
Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50344415
(CHEMBL1779844 | N-Isopropyl-6-phenylethynyl-nicoti...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 62nM
Assay Description:
Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as increase of L-glutamate-induced calcium mobilization by FLIPR as...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI