Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM207860(US9546153, ex. 35)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM207860(US9546153, ex. 35)
Affinity DataIC50:  2.60nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM207860(US9546153, ex. 35)
Affinity DataIC50:  480nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM207860(US9546153, ex. 35)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed