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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50448960
(CHEMBL3125540 | US9296736, 365 | US9593129, Exampl...)
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Affinity Data
IC50: 0.400nM
Assay Description:
Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM50448960
(CHEMBL3125540 | US9296736, 365 | US9593129, Exampl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM50448960
(CHEMBL3125540 | US9296736, 365 | US9593129, Exampl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
pH: 7.4 T: 2°C
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI