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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 35 hits in this display   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  180nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  180nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  200nMMore data for this Ligand-Target Pair
In DepthDetails
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  200nMMore data for this Ligand-Target Pair
In DepthDetails
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  240nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  240nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM50591663(CHEMBL5203189)
Affinity DataIC50:  280nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  310nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  310nMMore data for this Ligand-Target Pair
In DepthDetails
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  320nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  320nMMore data for this Ligand-Target Pair
In DepthDetails
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  320nMMore data for this Ligand-Target Pair
In DepthDetails
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  330nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  390nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  420nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  430nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  430nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  620nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  620nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  620nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  620nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  650nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  660nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  680nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  730nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  750nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataIC50:  750nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  760nM Kd:  110nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  1.14E+3nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataIC50:  1.14E+3nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to Bcl-XL by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to Bcl-XL by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to Bcl-XL by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to Bcl-XL by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed