Home
About
Info
Download
WebServices
Contact
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
Neprilysin
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
Assay Description:
50% inhibitory activity against enkephalinase purified from rat kidney with [3H]D-Ala2-Leu-enkephalin (20 nM) as substrate.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Homo sapiens (Human))
University Of Paris
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
Assay Description:
Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50405292
(CHEMBL2079630)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.80nM
Assay Description:
50% inhibitory activity against enkephalinase purified from rat kidney with [3H]D-Ala2-Leu-enkephalin (20 nM) as substrate.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aminopeptidase N
(Sus scrofa (Pig))
TBA
Curated by
ChEMBL
Ligand
BDBM50405292
(CHEMBL2079630)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.90nM
Assay Description:
Inhibitory activity against aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aminopeptidase N
(Sus scrofa (Pig))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.80nM
Assay Description:
Inhibitory activity against aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 10nM
Assay Description:
Inhibitory activity against LTA 4 hydrolase in aminopeptidase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Inhibitory activity against LTA 4 hydrolase in epoxide hydrolase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PDB
3D Structure (crystal)
Copy BDB DOI
Target
EEF1AKMT4-ECE2 readthrough transcript protein
(Homo sapiens (Human))
Pharmaleads
Ligand
BDBM92500
(Kelatorphan)
Copy SMILES
Copy InChI
Affinity Data
Ki: 195nM IC50: 380nM
Assay Description:
Inhibitory assay against ECE-2.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aminopeptidase N
(Homo sapiens (Human))
University Of Paris
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.00E+3nM
Assay Description:
Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1nM
Assay Description:
Inhibitory activity against Leu-enkeph of Neutral endopeptidase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70nM
Assay Description:
Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50020158
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
In vitro inhibition of enkephalinase purified from rat kidney.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Thermolysin
(Bacillus thermoproteolyticus)
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3nM
Assay Description:
Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibitory activity against recombinant human Leukotriene A4 hydrolase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibitory activity was determined against Leukotriene A4 hydrolase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Aminopeptidase N
(Sus scrofa (Pig))
TBA
Curated by
ChEMBL
Ligand
BDBM50020158
((R,S)2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.10nM
Assay Description:
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8nM
Assay Description:
Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8nM
Assay Description:
Inhibitory activity against big ET-1 of Neutral endopeptidase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 46nM
Assay Description:
Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
Copy BDB DOI
Target
Angiotensin-converting enzyme
(Oryctolagus cuniculus)
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibitory activity against rabbit lung angiotensin-converting enzyme (ACE)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibitory activity was determined for LTB4 production in human whole blood.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI