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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
43
hits in this display
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.70E+4nM
Assay Description:
Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80E+4nM
Assay Description:
Inhibition of human recombinant GST-tagged SIRT2 using acetylated HeLa histones substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80E+4nM
Assay Description:
Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
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PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80E+4nM
Assay Description:
Inhibition of recombinant human N-tagged GST-SIRT1 fusion protein using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetyl...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80E+4nM
Assay Description:
Inhibition of SIRT1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80E+4nM
Assay Description:
Inhibition of human GST-tagged SIRT1 (18 to 340 residues) expressed in Escherichia coli BL21 (DE3)LysS using acetylated HeLa histones as substrate me...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50177986
((S)-sirtinol | CHEMBL197282)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.94E+4nM
Assay Description:
Inhibitory activity against human SIRT2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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ChEBI
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Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.01E+4nM
T: 2°C
Assay Description:
Inhibition of human recombinant SIRT1 using Arg-His-Lys-Lys(epsilon-acetyl)-AMC at room temperature for 45 mins by fluorescent screening assay
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.51E+4nM
Assay Description:
Inhibition of human recombinant GST-tagged SIRT2 by histone deacetylase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.51E+4nM
Assay Description:
Inhibition of SIRT2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.58E+4nM
Assay Description:
Inhibition of human recombinant SIRT2 using Arg-His-Lys-Lys(epsilon-acetyl)-AMC at 37 degC for 45 mins by fluorescent screening assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.59E+4nM
Assay Description:
Inhibition of human recombinant SIRT2 by Flour de Lys assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.60E+4nM
Assay Description:
Inhibition of SIRT2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.60E+4nM
Assay Description:
Inhibition of human His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluores...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.71E+4nM
Assay Description:
Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent histone deacetylase SIR2
(Saccharomyces cerevisiae)
Sapienza University Of Rome
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.80E+4nM
Assay Description:
Inhibitory activity against recombinant yeast Sir2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase HST2
(Saccharomyces cerevisiae)
Institute
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.80E+4nM
Assay Description:
Inhibition of yeast Hst2 by fluorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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ChEBI
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PubMed
Copy BDB DOI
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.89E+4nM
Assay Description:
Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.92E+4nM
Assay Description:
Inhibition of recombinant human SIRT2 after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50177983
((R)-sirtinol | CHEMBL198582)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.93E+4nM
Assay Description:
Inhibitory activity against human SIRT2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.30E+4nM
Assay Description:
Inhibition of human recombinant SIRT2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.30E+4nM
Assay Description:
Inhibition of human recombinant Sirt2 expressed in Escherichia coli BL21 by fluorescent deacetylase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50177983
((R)-sirtinol | CHEMBL198582)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+4nM
Assay Description:
Inhibitory activity against human SIRT1
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.77E+4nM
Assay Description:
Inhibitory activity against human SIRT2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent histone deacetylase SIR2
(Saccharomyces cerevisiae)
Sapienza University Of Rome
Curated by
ChEMBL
Ligand
BDBM50177983
((R)-sirtinol | CHEMBL198582)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.20E+4nM
Assay Description:
Inhibitory activity against recombinant yeast Sir2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent histone deacetylase SIR2
(Saccharomyces cerevisiae)
Sapienza University Of Rome
Curated by
ChEMBL
Ligand
BDBM50177986
((S)-sirtinol | CHEMBL197282)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.60E+4nM
Assay Description:
Inhibitory activity against recombinant yeast Sir2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50177986
((S)-sirtinol | CHEMBL197282)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.70E+4nM
Assay Description:
Inhibitory activity against human SIRT1
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.80E+4nM
Assay Description:
Inhibition of human recombinant GST-tagged SIRT1 using acetylated HeLa histones substrate
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent histone deacetylase SIR2
(Saccharomyces cerevisiae)
Sapienza University Of Rome
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.80E+4nM
Assay Description:
Inhibition of recombinant yeast Sir2p using acetylated HeLa histones as substrate measured after 2 hrs in presence of NAD by scintillation counting m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
MCE
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In Depth
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Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.99E+4nM
Assay Description:
Inhibition of recombinant human SIRT1 after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.25E+4nM
Assay Description:
Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...
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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrate
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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of SIRT5
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Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.03E+5nM
Assay Description:
Inhibition of GST-tagged SIRT2 (18 to 340 residues) (unknown origin) expressed in Escherichia coli BL21-(DE3)LysS cells
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Target Info
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Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.03E+5nM
Assay Description:
Inhibition of recombinant human full length SIRT2 using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assay
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Target Info
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.20E+5nM
Assay Description:
Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assay
More data for this Ligand-Target Pair
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.23E+5nM
Assay Description:
Inhibition of human GST-tagged SIRT1 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluoresc...
More data for this Ligand-Target Pair
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Copy InChI
Affinity Data
IC50: 1.23E+5nM
Assay Description:
Inhibition of SIRT1
More data for this Ligand-Target Pair
Target Info
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.23E+5nM
Assay Description:
Inhibition of human recombinant SIRT1 by Flour de Lys assay
More data for this Ligand-Target Pair
Target Info
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.31E+5nM
Assay Description:
Inhibitory activity against human SIRT1
More data for this Ligand-Target Pair
Target Info
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Target
NAD-dependent protein deacetylase
(Leishmania infantum)
Jiangsu University
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.94E+5nM
Assay Description:
Inhibition of Leishmania infantum SIR2RP1
More data for this Ligand-Target Pair
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Target
NAD-dependent protein deacetylase
(Leishmania infantum)
Jiangsu University
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Affinity Data
IC50: 1.94E+5nM
Assay Description:
Inhibition of N-terminal His6-tagged recombinant Leishmania infantum SIR2RP1 expressed in Escherichia coli in presence of NAD+ by fluorimetric method
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Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50156760
((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
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Copy InChI
Affinity Data
IC50: 2.45E+5nM
Assay Description:
Inhibition of human SIRT1 in presence of NAD+ by fluorimetric method
More data for this Ligand-Target Pair
Target Info
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KEGG
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ChEBI
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Copy BDB DOI