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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Chymase
(Homo sapiens (Human))
Daiichi Sankyo
US Patent
Ligand
BDBM2228
(US8507714, 178A)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
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Target
Chymase
(Homo sapiens (Human))
Daiichi Sankyo
US Patent
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of human recombinant chymase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Chymase
(Homo sapiens (Human))
Daiichi Sankyo
US Patent
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Copy InChI
Affinity Data
IC50: 300nM
Assay Description:
Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Chymase
(Homo sapiens (Human))
Daiichi Sankyo
US Patent
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Copy InChI
Affinity Data
IC50: 300nM
Assay Description:
Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin G
(Homo sapiens (Human))
Daiichi Asubio Pharma
Curated by
ChEMBL
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of human cathepsin G
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin G
(Homo sapiens (Human))
Daiichi Asubio Pharma
Curated by
ChEMBL
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neutrophil elastase
(Homo sapiens (Human))
Asubio Pharma
Curated by
ChEMBL
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Chymase
(Homo sapiens (Human))
Daiichi Sankyo
US Patent
Ligand
BDBM50210730
(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
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Copy InChI
Affinity Data
K
on
: 1.25E-7M
-1
s
-1
Assay Description:
Binding affinity to recombinant human chymase assessed as dissociation constant at 6 to 1000 nM by SPR assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI